Bad News Thread

If a prior infection is as effective as a vaccine, then verified prior infections should also count. But they probably won’t.

Anti-vax people with prior infections are not very popular in places with high vax rates. There is a lot of anger at the anti-mask, anti-vax contingent, based on the accurate belief that they helped cause this by running around spreading it the last 15 months. I would not expect the SF or NY public health officials to carve out an extra exemption for anti-vax folks who get themselves infected.
Let's see how the high vax areas respond to a mandated third shot. Lol!!
 
It's unfortunate the criterion of circulating antibody levels is being either misunderstood or deliberately misused in some cases. With a natural infection, symptomtic or not, the immune systems"sees" a large number of different surfaces of the virus. There is therefore a large antibody production response and a high titer of circulating antibodies. However, only a relatively small fraction of these antibodies can block the interaction between the spike protein and the Ace2 receptor, and thus prevent a second infection. The circulating levels of those so-called neutralizing antibodies will drop over time, at which point offsetting a second infection will require "waking up" the immune system memory cells to produce those antibodies from scratch.

With the vaccine the absolute AMOUNT of circulating antibody after the second booster may not be as high as natural infection, But the FRACTION of those antibodies that can block the interaction between the spike protein and Ace2 is higher, since that is the only target the immune system is seeing. As with natural infection, the level of those antibodies will decline over time as well, at which point antibody production will require waking up the memory cells. But studies have shown that a very high fraction of the resulting memory cells arising after vaxx can produce potent neutralizing antibodies. Which is why the vaccines are working so well at uncoupling cases and deaths in high vaxxed vulnerable people. Even if a second infection gets established eventually that sweet immunity kicks in and takes care of things. The same thing happens with natural immunity too, but the spectrum of antibodies that can produced upon re-infection is more hit and miss.

Anyway the total antibody concentration stuff is being misappropriated to argue natural immunity is better than the vaxx, which is just kind of silly. How long circulating antibody levels can be sustained at levels necesessary to directly prevent re-infection in either case is subject to lots of variables. And with a high replicating variant like delta keeping circulating neutralizing antibody levels high enough to prevent any sort of viral propagation is going to be really challenging, no matter how you prime the immune system, especially with a super sensitize detection method like PCR.
You're not describing anything new above
 
Is there any good evidence on the degree to which prior infections are effective at limiting Delta infections?

Maybe. IMO would have to normalize for lots of other variables. I think the confidence intervals would be large so need big numbers to say anything with statistical relevance.

Kind of ironic but I think there is an argument that the best way to drive down community transmission with delta is low tech NPIs. But it would take substantial buy in and in this country its just not going to happen. I came across a nice review of masks a bit ago, peer reviewed, well done, not a think tank thing. Went through the history of how masks have been around long time, interwoven into basic concepts of hygiene. Mamma saying "grab a damn tissue when you sneeze and don't double dip the guac". Same idea. And now epidemiologists have these mathematical models where can plug in different participation rates, different R0s and see how much buy in need to make a difference.

The study I'd like to see right now is how much neutralizing Ab memory is out there in the <12 year old crowd. Since its probably still going to be a bit since they have the option for the jab.
 
How could they have done better? And better than who? They did better than most of the panicked world according to their needs. Not the socialist one size fits all policies that have been peddled throughout the world.

What could be more interesting than zero deaths over the last month given that "Sweden didn't do as good a job as they needed to there."

Late last year Internal government study concluded that with their approach to the pandemic they needed to implement better isolation of nursing homes patients to prevent their big first wave.
 
I like how your concluding sentence touches on one of the main issues with what we are doing.

that's why studies like the one I posted earlier with the Ct values are key. A lot of what the media are calling breakthrough infections are probably not much of an infection at all. At any rate, beats the human Ace2 adapted gerbil test.
 
Maybe. IMO would have to normalize for lots of other variables. I think the confidence intervals would be large so need big numbers to say anything with statistical relevance.

Kind of ironic but I think there is an argument that the best way to drive down community transmission with delta is low tech NPIs. But it would take substantial buy in and in this country its just not going to happen. I came across a nice review of masks a bit ago, peer reviewed, well done, not a think tank thing. Went through the history of how masks have been around long time, interwoven into basic concepts of hygiene. Mamma saying "grab a damn tissue when you sneeze and don't double dip the guac". Same idea. And now epidemiologists have these mathematical models where can plug in different participation rates, different R0s and see how much buy in need to make a difference.

The study I'd like to see right now is how much neutralizing Ab memory is out there in the <12 year old crowd. Since its probably still going to be a bit since they have the option for the jab.
The low level npis aren’t driving down cases in heavily vaccinated Israel or Iceland. Even if you assume argue so they did something against covid prime, they don’t seem to be working as well against the delta. Even Oster has said cloth masks are useless. At this point by way of masking you are looking at n95s on everyone (which for kids in school is not a low level intervention) or surgicals with some enhancement. Even with heavy handed npis australia is struggling to contain the delta
 
Thanks.

Doesn’t say much about immunity. It may just be that, if you were prone to catch respiratory diseases in December, you were still prone to catch respiratory diseases in July.

Or it may slice the other way. People who had covid probably don’t suddenly decide to take larger risks. But people who get vaccines definitely do.
 
Not much to that article or information regarding their study. Just "I think that is very likely because we know the Delta variant is so much more infectious," said Dr. Srivastava.

So know real data showing one (vax) versus the other (previous infection). Again, I’m open minded and genuinely curious (until the name calling starts).
 
Late last year Internal government study concluded that with their approach to the pandemic they needed to implement better isolation of nursing homes patients to prevent their big first wave.
Wonder if the study takes in to account that theres not much you can do about being (70) elderly at some point. Just ask the insurance companies. Ever wonder why you can get term insurance for cheap but usually for not longer than 30 years? And if you want to extend it another 30 years 'till you're 70 plus, won't be able to afford that policy. It's been like that for a very long time despite deadly viruses. No need to go all scientific on us. The actuaries cut right through all of the bullshit to get to death$. Show me an increase in Premiums for term life and just maybe you can convince me that "better" one size fits all policies could have helped Sweden do better.
 
FREAKIN' HILARIOUS

Here is a survey, just completed (so this isn't from April 2020, bear in mind), of "infectious disease experts."

Red is a NO answer.



quentionare-responses@2x-80-768x793.jpg

Surveys such as this one reveal that the epidemiology profession is a hotbed of statistical illiterates, paranoiacs, and outright crazy people.

Similar surveys in the past have revealed a high prevalence of other bizarre behavioral patterns by epidemiologists, such as refusing to touch their mail for three days out of fear that it contains Covid. [TW note: The New York Times reported on this last summer; one-third of epidemiologists surveyed were refusing to get their mail. As of two months ago, 17% of them were still afraid of their mail.]

These results are not coming from the fringes of the profession either, but rather its "leading" voices. For example, the survey depicted in the image included Michael Osterholm -- a former member of Biden's covid task force and a prominent lockdowner spokesman on TV for the last year.

If innumeracy, absurd distortions of risk assessment, and quack beliefs about taking radical steps to avoid safe and common public activities are indeed widespread among epidemiologists, perhaps we should stop treating these people as experts and instead look upon their advice as one would view medical advice from an astrologer or homeopath.


(Please, homeopath friends, do not send me angry emails. I am simply including the entire quotation.)

It is this insane, lunatic standard that is used to "fact check" the normal people.

People who are afraid of their mail want to "fact check" you.

Hence the need for uncensored discussion among intelligent people without being "fact checked" by hypochondriacs.
 
Not much to that article or information regarding their study. Just "I think that is very likely because we know the Delta variant is so much more infectious," said Dr. Srivastava.

So know real data showing one (vax) versus the other (previous infection). Again, I’m open minded and genuinely curious (until the name calling starts).
 
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